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What time of day should risperidone be taken? Your doctor will tell you how often to give it. Once a day : this is usually in the evening. Twice a day : this should be once in the morning and once in the evening. Ideally these times are 10вЂ“12 hours apart, for example some time between 7 and 8 am, and between 7 and 8 pm. Do antipsychotics kill brain cells? But according to a new study, long-term use of these drugs may also negatively impact brain structure. Researchers say long-term use of antipsychotic medications - particularly first-generation antipsychotics - may lead to gray matter loss in the brain. What are first generation antipsychotic medications? This was the first drug used as an antipsychotic, and is still in use. Other drugs in this group include loxapine, fluphenazine, perphenazine, haloperidol and loxapine. First generation antipsychotics are classified according to their chemical family, which predicts clinical profile.
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